科学与环境

Cancer stem cells have an “energy addiction” scientists may be able to exploit

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High-risk MDS stem cells appear to have an unexpected “energy addiction,” relying far more heavily than healthy blood-forming cells on a molecule called NAD. Disrupting this energy pathway selectively weakened the cancer-driving cells, revealing a potential new target for treatme

High-risk MDS stem cells appear to have an unexpected “energy addiction,” relying far more heavily than healthy blood-forming cells on a molecule called NAD. Disrupting this energy pathway selectively weakened the cancer-driving cells, revealing a potential new target for treatment.

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科学与环境

Cancer-fighting t cells burn out. Scientists may have found a fix

Cancer immunotherapy can lose its punch when tumor-fighting T cells become exhausted, but researchers may have found a way to keep them going longer. Scientists at Memorial Sloan Kettering Cancer Center identified a signaling molecule called MEK that can push T cells to burn thro

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科学与环境

The “glue” holding your cells together has a surprising second job

Scientists have discovered that E-cadherin, a protein best known as the “glue” holding cells and tissues together, has a surprising second job: helping epithelial cells swallow nearby dead cells. Using live zebrafish and mouse embryos, researchers found that cells can dramaticall

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科学与环境

Vitamin D drug may help crack pancreatic cancer’s protective shield

A vitamin D analog may help break down pancreatic cancer’s protective defenses, potentially making tumors more vulnerable to chemotherapy and immune attack. A small clinical trial found encouraging responses, especially in patients whose tumors had high levels of the vitamin D re

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