科学与环境
AI structure prediction speeds discovery of 'molecular glues' to treat disease
来源: Phys.org - latest science and technology news stories · 发布于
A Baylor College of Medicine-led team has developed a strategy that combines the analysis of thousands of proteins with artificial intelligence to accelerate the discovery of small molecules called molecular glues to treat disease. Their approach, published in Nature Communicatio
A Baylor College of Medicine-led team has developed a strategy that combines the analysis of thousands of proteins with artificial intelligence to accelerate the discovery of small molecules called molecular glues to treat disease. Their approach, published in Nature Communications, has uncovered a new class of molecular glues that could neutralize harmful proteins linked to blood cancers and autoimmune diseases. The work also shows how AI-based structural modeling can help chemists optimize compounds well before experiments reveal how they work.
相关报道
Molecular simulations reveal how an enzyme's shape guides molecular recognition
Enzymes are often described as molecular machines that recognize and process specific molecules. However, they are not rigid structures. Their shapes can change, affecting how molecules enter, interact with and remain within their active sites.
Phys.org - latest science and technology news stories ·
New feathered, winged dinosaur from China challenges our theories on bird and dinosaur evolution
A newly described feathered dinosaur found in northeastern China adds evidence supporting the theory that flight-related features evolved differently in various bird-like dinosaur groups. The findings, reported in Nature Communications, are based on an analysis of an exceptionall
Phys.org - latest science and technology news stories ·
Nine generations of virtual dating reveal how fish shape their ideal mates
Fish have "designed" their perfect partners in a new experiment—revealing simple male preferences and more complex female tastes.
Phys.org - latest science and technology news stories ·
Revisiting a Young Isaac Newton
Isaac Newton is typically portrayed as a solitary scientist with intense focus who was obsessed with power and deeply egotistical. But a new book by Caltech historians Jed Buchwald and Mordechai Feingold takes a deeper look at Newton's life in the two decades leading up to the 16
Phys.org - latest science and technology news stories ·
Why monkeys handle conflicts better than we do
Conflicts with our colleagues, loved ones or team members can quickly stifle communication, heighten tensions and undermine relationships. However, a decision or compromise is not always enough to restore cooperation—for a solution to last, we must also repair the bond that will
Phys.org - latest science and technology news stories ·