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Novel chemical reaction expands options for building DNA-encoded libraries
المصدر: Phys.org - latest science and technology news stories · نُشر
Finding new drugs requires screening vast numbers of compounds to identify those that interact with a biological target. DNA-encoded libraries (DELs) help researchers explore these large collections by attaching a short DNA sequence to each molecule, acting as a molecular barcode
Finding new drugs requires screening vast numbers of compounds to identify those that interact with a biological target. DNA-encoded libraries (DELs) help researchers explore these large collections by attaching a short DNA sequence to each molecule, acting as a molecular barcode that allows compounds with promising properties to be identified.
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Different transcription systems shape chromatin behavior in distinct nuclear regions
Inside the cell nucleus, DNA is wrapped around histone proteins to form nucleosomes, which are further organized into chromatin. Chromatin has traditionally been divided into transcriptionally active euchromatin and relatively inactive heterochromatin. However, chromatin is not a
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Pulling the strings: How stem cells in the developing fruit fly brain organize their DNA from outside the nucleus
Cells are very particular about the proper locations of their contents. For example, DNA is packaged in the nucleus in a highly specific way, but researchers are still trying to understand how this happens. For stem cells in the brain of a larval fruit fly—a model organism used t
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The asteroid that killed the dinosaurs may have helped ants conquer the world
The asteroid that killed the dinosaurs may have set the stage for ants to conquer the planet, with a surprising boost from “jumping genes” hidden in their DNA. Scientists discovered that bursts of activity from these mobile genetic elements coincided with the rise of major ant gr
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Scientists discover how pancreatic cancer rewrites its DNA to escape treatment
Scientists have discovered how pancreatic cancer cells continually reshape their genetic makeup to become more aggressive, spread, and evade treatment. In laboratory experiments, blocking a key gene reversed some of these dangerous changes, revealing a potential new way to fight
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Why it could be a bad idea to get AI to flirt for you
You finally started an online conversation with a stranger you find attractive, yet you don't really know what to say. They seem happy to talk, but you struggle to find the correct responses. You worry that their patience is growing thin. You pray for some guidance. Luckily, the
Phys.org - latest science and technology news stories ·