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Chain reaction that begins when tumor suppression gene is switched off offers clues to how cancer develops
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A tumor suppressor gene known as p53 is mutated in more than half of all cancers, but how it acts to prevent cancer formation is largely unknown. A study by UT Southwestern Medical Center researchers sheds light on this phenomenon by showing what happens when p53 becomes disabled
A tumor suppressor gene known as p53 is mutated in more than half of all cancers, but how it acts to prevent cancer formation is largely unknown. A study by UT Southwestern Medical Center researchers sheds light on this phenomenon by showing what happens when p53 becomes disabled, revealing the gene's diverse roles in maintaining healthy metabolic activity, repressing mobile genes called retrotransposons and preventing cells from adopting features of sperm and eggs.
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Cancer-fighting t cells burn out. Scientists may have found a fix
Cancer immunotherapy can lose its punch when tumor-fighting T cells become exhausted, but researchers may have found a way to keep them going longer. Scientists at Memorial Sloan Kettering Cancer Center identified a signaling molecule called MEK that can push T cells to burn thro
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Earth’s center is moving, and NASA just measured it
Earth’s center of mass is constantly on the move, shifting by a few millimeters as enormous amounts of water, ice, and even air migrate around the planet with the seasons. NASA scientists have developed a more precise way to track these tiny swings using laser-ranging satellites,
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Vitamin D drug may help crack pancreatic cancer’s protective shield
A vitamin D analog may help break down pancreatic cancer’s protective defenses, potentially making tumors more vulnerable to chemotherapy and immune attack. A small clinical trial found encouraging responses, especially in patients whose tumors had high levels of the vitamin D re
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Cancer stem cells have an “energy addiction” scientists may be able to exploit
High-risk MDS stem cells appear to have an unexpected “energy addiction,” relying far more heavily than healthy blood-forming cells on a molecule called NAD. Disrupting this energy pathway selectively weakened the cancer-driving cells, revealing a potential new target for treatme
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Five ways to enjoy fashion as a hobby without indulging in overconsumption
Fashion lovers are generally associated with bursting wardrobes and chasing the latest trends. But that reputation is beginning to shift.
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