العلوم والبيئة
AI structure prediction speeds discovery of 'molecular glues' to treat disease
المصدر: Phys.org - latest science and technology news stories · نُشر
A Baylor College of Medicine-led team has developed a strategy that combines the analysis of thousands of proteins with artificial intelligence to accelerate the discovery of small molecules called molecular glues to treat disease. Their approach, published in Nature Communicatio
A Baylor College of Medicine-led team has developed a strategy that combines the analysis of thousands of proteins with artificial intelligence to accelerate the discovery of small molecules called molecular glues to treat disease. Their approach, published in Nature Communications, has uncovered a new class of molecular glues that could neutralize harmful proteins linked to blood cancers and autoimmune diseases. The work also shows how AI-based structural modeling can help chemists optimize compounds well before experiments reveal how they work.
أخبار ذات صلة
Molecular simulations reveal how an enzyme's shape guides molecular recognition
Enzymes are often described as molecular machines that recognize and process specific molecules. However, they are not rigid structures. Their shapes can change, affecting how molecules enter, interact with and remain within their active sites.
Phys.org - latest science and technology news stories ·
New feathered, winged dinosaur from China challenges our theories on bird and dinosaur evolution
A newly described feathered dinosaur found in northeastern China adds evidence supporting the theory that flight-related features evolved differently in various bird-like dinosaur groups. The findings, reported in Nature Communications, are based on an analysis of an exceptionall
Phys.org - latest science and technology news stories ·
Small fields, great diversity: How a diverse patchwork of crops helps birds
Birds are not only beautiful to look at and listen to; they also play important roles in nature. They eat pests and disperse seeds. They are generally considered indicators of a healthy environment. When birds thrive, soil and water quality often benefit as well. A new study publ
Phys.org - latest science and technology news stories ·
Engineered coating lets mitochondria retain their ability to produce energy
Researchers have coated mitochondria with innovative materials without compromising their function, according to a study by IRCCS Fondazione Istituto Neurologico Carlo Besta (FINCB) and Politecnico di Milano. The research was conducted as part of the BraiNs joint laboratory, inau
Phys.org - latest science and technology news stories ·
NYC delivery workers injured at more than five times national rate under intense labor control by apps, survey finds
More than half of New York City's app-based food delivery workers have been injured on the job, and 40% meet the criteria for severe psychological distress, according to a new study from the CUNY Graduate School of Public Health and Health Policy (CUNY SPH), in partnership with t
Phys.org - latest science and technology news stories ·